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Angiotensin II human

參考價(jià)825.00-5500.00
具體成交價(jià)以合同協(xié)議為準(zhǔn)
  • 公司名稱杭州昊鑫生物科技股份有限公司
  • 品       牌MCE
  • 型       號(hào)HY-13948
  • 所  在  地杭州市
  • 廠商性質(zhì)代理商
  • 更新時(shí)間2023/5/22 12:25:20
  • 訪問(wèn)次數(shù)609
規(guī)格
10 mg825.00元10000 支可售
50 mg3069.00元10000 支可售
100 mg5500.00元10000 支可售
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胎牛血清、MCE抑制劑激動(dòng)劑、RNA提取試劑盒、ELISA試劑盒、重組蛋白
CAS號(hào) 4474-91-3 產(chǎn)地 進(jìn)口
級(jí)別 其他
Angiotensin II (Angiotensin II) 是一種血管收縮劑,是腎素/血管緊張素系統(tǒng)的主要生物活性肽。Angiotensin II human 在調(diào)節(jié)人類血壓中起著核心作用,主要通過(guò)血管緊張素 II 與 G 蛋白偶聯(lián)受體 (GPCRs)、血管緊張素II 1型受體 (AT1R) 和血管緊張素II 2型受體 (AT2R) 之間的相互作用來(lái)介導(dǎo)。Angiotensin II huma
Angiotensin II human 產(chǎn)品信息


注:本產(chǎn)品僅用于科研,不可用于臨床

生物活性

血管緊張素ⅱ(血管緊張素ⅱ)是一種血管收縮劑和腎素-血管緊張素系統(tǒng)的主要生物活性肽。血管緊張素ⅱ人類中起著重要的作用在調(diào)節(jié)人體血壓,主要由血管緊張素ⅱ和G-protein-coupled受體之間的相互作用(GPCRs)血管緊張素ⅱ1型受體(AT1R)和血管緊張素ⅱ2型受體(AT2R)。血管緊張素ⅱ人類刺激交感神經(jīng)的刺激,增加醛固酮生物合成和腎的行動(dòng)。人類血管緊張素ⅱ誘導(dǎo)的血管平滑肌細(xì)胞,增加膠原蛋白I型和III在成纖維細(xì)胞合成,導(dǎo)致血管壁增厚和心肌纖維化。血管緊張素ⅱ人類也誘發(fā)細(xì)胞凋亡。血管緊張素ⅱ誘導(dǎo)形成毛細(xì)血管內(nèi)皮細(xì)胞通過(guò)LOX-1依賴redox-sensitive途徑。.

IC50 & Target




AT1 Receptor

AT2 Receptor

體外研究
(In Vitro)

大多數(shù)已知的血管緊張素ⅱ(Ang II)行動(dòng)由AT1受體介導(dǎo),at?受體有助于調(diào)節(jié)血壓和腎臟功能[1]
. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1)[2].
Angiotensin II (1 nM) induces the expression of LOX-1 and VEGF and enhances capillary formation from human coronary endothelial cells in Matrigel assay. Angiotensin II -mediated expression of LOX-1 and VEGF, capillary formation, intracellular reactive oxygen species generation, and phosphorylation of p38 as well as p44/42 mitogen-activated protein kinases, are suppressed by anti-LOX-1 antibody, nicotinamide-adenine dinucleotide phosphate oxidase inhibitor apocynin and the Ang II type 1 receptor blocker Losartan, but not by the Ang II type 2 receptor blocker PD123319[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Angiotensin II human (5 mL of 1 nM; intraperitoneal injection; 200-250 g Sprague-Dawley rats) induces a significant neutrophil recruitment that was maximal at 4 hours and had resolved by 24 hours[4].
To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1046.18

性狀

Solid

Formula

C50H71N13O12

CAS 號(hào)

4474-91-3

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

Sequence Shortening

DRVYIHPF

中文名稱

血管緊張素Ⅱ

結(jié)構(gòu)分類
  • Others

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Sealed storage, away from moisture and light, under nitrogen

Powder-80°C2 years

-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性數(shù)據(jù)
In Vitro:

DMSO : 100 mg/mL (95.59 mM; Need ultrasonic)

H2O : 50 mg/mL (47.79 mM; Need ultrasonic)

配制儲(chǔ)備液
濃度溶劑體積質(zhì)量1 mg5 mg10 mg
1 mM0.9559 mL4.7793 mL9.5586 mL
5 mM0.1912 mL0.9559 mL1.9117 mL
10 mM0.0956 mL0.4779 mL0.9559 mL
*

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 儲(chǔ)存時(shí),請(qǐng)?jiān)?6 個(gè)月內(nèi)使用,-20°C 儲(chǔ)存時(shí),請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮R韵氯芙夥桨付颊?qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑:

——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比;如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過(guò)加熱和/或超聲的方式助溶

  • 1.


    請(qǐng)依序添加每種溶劑: PBS

    Solubility: 30 mg/mL (28.68 mM); Clear solution; Need ultrasonic


  • 2.


    請(qǐng)依序添加每種溶劑: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.39 mM); Clear solution


  • 3.


    請(qǐng)依序添加每種溶劑: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.39 mM); Clear solution


  • 4.


    請(qǐng)依序添加每種溶劑: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (0.79 mM); Clear solution





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