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C-反應蛋白抗體Anti-CRP相關(guān)標記    Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC  
英文名稱    CRP
中文名稱    C-反應蛋白抗體
研究領域    心血管  免疫學  信號轉(zhuǎn)導  細胞凋亡  生長因子和激素  
抗體來源    Rabbit
克隆類型    Polyclonal
交叉反應    Human, Mouse, Rat, Dog, Pig, Rabbit, 
產(chǎn)品應用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500（石蠟切片需做抗原修復） 
 not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    25kDa
細胞定位    分泌型蛋白 
性    狀    Lyophilized or Liquid
濃    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human CRP (151-200aa)
亞    型    IgG
純化方法    affinity purified by Protein A
儲 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹    background:
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P ponent (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the mon pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.

Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and plement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Subunit:
Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular Location:
Secreted.

Tissue Specificity:
Found in plasma.

Similarity:
Belongs to the pentaxin family.
Contains 1 pentaxin domain.

Gene ID:
1401

Database links:
Entrez Gene: 1401 Human
Omim: 123260 Human
SwissProt: P02741 Human
Unigene: 76452 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

C反應蛋白 CRP（C-reactive protin）是與C性肺炎球菌的多糖起反應的一種蛋白，在某些細菌的感染過程中出現(xiàn)在血漿中。
CRP是在一些病理性情況下出現(xiàn)于病人血清中的一種糖蛋白，特別是在伴有肯炎癥和組織壞死疾病的急性期。血清中出現(xiàn)的這種異常蛋白能和肺炎C-多糖體發(fā)生沉淀反應，當疾病好轉(zhuǎn)或緩解時，CRP減低或消失。
臨床意義:
(1)各種急性化膿性炎癥、菌血癥、組織壞死(心肌梗塞、手術(shù)、嚴重創(chuàng)傷、燒傷等)、惡性腫瘤、結(jié)締組織病、腎移殖后急性排異反應、急性風濕熱、風濕性關(guān)節(jié)炎、類風濕性關(guān)節(jié)炎、心肌炎急性期、肺炎、肺結(jié)核、系統(tǒng)性紅斑狼瘡、急性肝炎和闌尾炎等，血清中CRP含量可增高，它的出現(xiàn)比其它急性期的反應物質(zhì)早，所以對疾病的早期診斷很有幫助。
CRP可以鑒別細菌炎癥或者是病毒性炎癥。細菌性炎癥CRP可以明顯增高，而病毒性炎癥CRP的血清含量一般都在正常范圍。
產(chǎn)品圖片    
Antigen: bs-0155P, 0.2ug/100ul 
Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; 
Secondary: HRP conjugated Goat-Anti- Rabbit IgG(bs-0295G-HRP) at 1: 5000; 
TMB(C-0024) staining; 
Read the data in MicroplateReader by 450nm. 

Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-CRP Polyclonal Antibody, Unconjugated(bs-0155R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

Tissue/cell: mouse intestine tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-CRP Polyclonal Antibody, Unconjugated(bs-0155R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining