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HY-15142
MCE
代理商
杭州市
10 mM * 1 mL in DMSO 990元 10000支可售
50 mg 900元 10000支可售
100 mg 1600元 10000支可售
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更新時間:2023-05-22 15:23:43瀏覽次數(shù):258次
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注:本產(chǎn)品僅用于科研,不可用于臨床
生物活性 | Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy[1][2][3]. | ||||||||||||||||||||
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IC50 & Target[1][2][3] |
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體外研究 (In Vitro) | Doxorubicin hydrochloride (1-8 µM; 24 and 48 hours) decreases the viability of MCF-10F, MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[4]
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體內(nèi)研究 (In Vivo) | Treatment with Doxorubicin (2 mg/kg) or Zoledronic acid (100 μg/kg) alone does not statistically significantly decrease final tumor volume compared with saline. Mice treated with Doxorubicin plus Zoledronic acid have statistically significantly smaller final tumor volumes than those treated with Doxorubicin alone[6]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 | 579.98 | ||||||||||||||||||||
性狀 | Solid | ||||||||||||||||||||
Formula | C27H30ClNO11 | ||||||||||||||||||||
CAS 號 | 25316-40-9 | ||||||||||||||||||||
中文名稱 | |||||||||||||||||||||
結(jié)構(gòu)分類 |
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來源 | Streptomyces peucetius var. Caesius | ||||||||||||||||||||
運(yùn)輸條件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
儲存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||||||
溶解性數(shù)據(jù) | In Vitro: DMSO : 35.71 mg/mL (61.57 mM; ultrasonic and warming and heat to 60°C) H2O : 20 mg/mL (34.48 mM; Need ultrasonic) 配制儲備液
* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。 In Vivo: 請根據(jù)您的實(shí)驗(yàn)動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都請先按?In Vitro 方式配制澄清的儲備液,再依次添加助溶劑: ——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲備液可以根據(jù)儲存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
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