當前位置:杭州昊鑫生物科技股份有限公司>>MCE>>生物試劑>> HY-17394Cisplatin試劑
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IC50 & Target | DNA Alkylator/Crosslinker[1] | ||||||||||||||||||||
體外研究 (In Vitro) | Cisplatin (CDDP) causes apoptosis of HeLa cells in a dose-dependent manner, with a concentration of 30 μM Cisplatin resulting in death of greater than 90% of the cell population by 24 h of treatment. The kinetics of Cisplatin-induced apoptosis are examined using a 30 μM concentration. Cisplatin Activates the MEK/ERK Signaling Pathway, 20 and 30 μM Cisplatin, both of which results in significant apoptosis, leads to strong activation of ERK[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||||||
體內研究 (In Vivo) | In melanoma-bearing mice, Cisplatin (CDDP; 4 mg/kg B.W.) reduces the size and weight of the solid tumors, and HemoHIM supplementation with Cisplatin enhances the decrease of both the tumor size and weight[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||||||
Clinical Trial |
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分子量 | 300.05 | ||||||||||||||||||||
性狀 | Solid | ||||||||||||||||||||
Formula | Cl2H6N2Pt | ||||||||||||||||||||
CAS 號 | 15663-27-1 | ||||||||||||||||||||
中文名稱 | |||||||||||||||||||||
運輸條件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
儲存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||||||
溶解性數(shù)據(jù) | In Vitro: DMF : 5 mg/mL (16.66 mM; Need ultrasonic; DMSO can inactivate Cisplatin's activity) H2O : 1 mg/mL (3.33 mM; ultrasonic and warming and heat to 60°C; DMSO can inactivate Cisplatin's activity) 配制儲備液
* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復凍融造成的產品失效。 In Vivo: 請根據(jù)您的實驗動物和給藥方式選擇適當?shù)娜芙夥桨?。以下溶解方案都請先按?In Vitro 方式配制澄清的儲備液,再依次添加助溶劑: ——為保證實驗結果的可靠性,澄清的儲備液可以根據(jù)儲存條件,適當保存;體內實驗的工作液,建議您現(xiàn)用現(xiàn)配,當天使用; 以下溶劑前顯示的百
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注:本產品僅用于科研,不可用于臨床
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